Dabigatran Etexilate iMpurity D synthesis
- Product Name:Dabigatran Etexilate iMpurity D
- CAS Number:1422435-40-2
- Molecular formula:C19H20N4O3
- Molecular Weight:352.39
64-17-5
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![3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester](/CAS2/GIF/211915-84-3.gif)
211915-84-3
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1422435-40-2
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Yield:-
Reaction Conditions:
Stage #1:ethanol;3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester with hydrogenchloride in dichloromethane at 15 - 30; for 6 h;
Stage #2: with ammonia in ethanol
References:
ALEMBIC PHARMACEUTICALS LIMITED;JAYARAMAN, Venkatraman;PATEL, Samir;MISTRY, Samir;TIMBADIYA, Mukesh;PARMAR, Bhupendra;TAMBOLI, Parimal WO2013/24394, 2013, A1 Location in patent:Page/Page column 20