一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Deferiprone
30652-11-0

Deferiprone synthesis

10synthesis methods
Deferiprone is a drug that chelates iron and is used to treat thalassaemia major. In 1994 was first approved for use in treating thalassaemia major in 1994 and had been licensed for use in Europe and Asia for many years while awaiting approval in Canada and the United States. On October 14, 2011, it was approved for use in the US under the FDA?’s accelerated approval program.
Synthetic Routes
  • ROUTE 1

    • 202112077391666935.jpg

    Dobbin, Paul S.; Hider, Robert C.; Hall, Adrian D.; Taylor, Paul D.; Sarpong, Patience; Porter, John B.; Xiao, Gaoyi; van der Helm, Dick. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential. Journal of Medicinal Chemistry. Volume 36. Issue 17. Pages 2448-58. Journal. (1993).

  • ROUTE 2

    • 202112070063819108.jpg

    Fox, Raymond C.; Taylor, Paul D. Efficient syntheses of N-alkyl-3-hydroxy-2-methyl-4(1H)-pyridinones from carbohydrate precursors. Synthetic Communications. Volume 29. Issue 6. Pages 989-1001. Journal. (1999).

202112077391666935.jpg

Dobbin, Paul S.; Hider, Robert C.; Hall, Adrian D.; Taylor, Paul D.; Sarpong, Patience; Porter, John B.; Xiao, Gaoyi; van der Helm, Dick. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential. Journal of Medicinal Chemistry. Volume 36. Issue 17. Pages 2448-58. Journal. (1993).

-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 99 percent / KOH / methanol / Ambient temperature
2: 99 percent / ethanol / 22 h / Ambient temperature
3: 80 percent / H2 / Pd/C / methanol / 2 h

References:

Rumbo, Antonio;Mourino, Antonio;Castedo, Luis;Mascarenas, Jose L. [Journal of Organic Chemistry,1996,vol. 61,# 18,p. 6114 - 6120]

FullText

那曲县| 龙泉市| 安岳县| 厦门市| 宜都市| 富宁县| 新竹县| 会泽县| 荔波县| 阳信县| 全南县| 江华| 聂拉木县| 松江区| 麟游县| 东乡县| 安泽县| 津市市| 临城县| 将乐县| 龙陵县| 通渭县| 长春市| 定安县| 贡觉县| 西乡县| 石嘴山市| 淳安县| 简阳市| 隆安县| 璧山县| 清水县| 沈阳市| 翁牛特旗| 海林市| 额尔古纳市| 安徽省| 文昌市| 凭祥市| 灵璧县| 神池县|