Dexrazoxane synthesis
- Product Name:Dexrazoxane
- CAS Number:24584-09-6
- Molecular formula:C11H16N4O4
- Molecular Weight:268.27
15250-41-6
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24584-09-6
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Yield:24584-09-6 87%
Reaction Conditions:
with ammonium formate in water;N,N-dimethyl-formamide at 150; for 10 h;Solvent;Reagent/catalyst;
Steps:
1-6 Example 1
Preparation of dextroimideAdd (S) -1,2-diaminopropane-tetraacetic acid (10g) to a reaction flask equipped with a water separator,Add N, N-dimethylformamide (50ml) and ammonium formate (20.6g) and heat to 150 ° C.The reflux was separated by a water separator, the reaction was stirred for 10 hours, and concentrated.Add 20ml of purified water and stir for 0.5 hours,Filtration and drying gave 7.1 g of crude dextroimine (81% yield),HPLC purity 99.2%.Add crude dextroimide to the reaction flask, add N, N-dimethylformamide (14ml), heat to 80 ° C, stir to dissolve, add absolute ethanol (64ml), and cool down to 20 ° C-30 ° C for crystallization Stir for 1 hour, filter and dry6.2 g (yield 87%) was obtained, and the HPLC purity was 99.83%.
References:
Yangzijiang Pharmaceutical Group Co., Ltd.;Zhou Weihai;Xu Haoyu;Cai Wei;Gao Xiaogang;Chen Zizhang;Huang Shuping;Hao Xiubin;Li Haodong;Xia Yu CN110804022, 2020, A Location in patent:Paragraph 0031-0050
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1029441-44-8
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24584-09-6
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$5.00/1mg
4408-81-5
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$73.50/10g
24584-09-6
310 suppliers
$5.00/1mg