DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE] synthesis
- Product Name:DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE]
- CAS Number:14111-33-2
- Molecular formula:C15H18O4
- Molecular Weight:262.3
104-87-0
526 suppliers
$6.00/25g
105-53-3
809 suppliers
$5.00/25g
14111-33-2
23 suppliers
$244.00/500mg
Yield:14111-33-2 99%
Reaction Conditions:
with piperidine;acetic acid in ethanol at 110; for 48 h;Knoevenagel Condensation;
Steps:
Synthesis of 2-Substituted dicarbonyl ester 1,3-Dienes
General procedure: In a round bottom flask was added malonate (93 mmol) and aldehyde (110 mmol) in absolute ethanol (40mL), then acetic acid (17 mmol) and piperidine (15 mmol). The reaction vessel was heated to reflux for 48 hours2.Then by-product was distilled in a Kugelrohr apparatus under vacuum. The desired compound was obtained with anexcellent yield.
References:
Rousseau, Olivier;Delaunay, Thierry;Robiette, Rapha?l [Synlett,2014,vol. 25,# 4,art. no. ST-2013-D1027-L,p. 519 - 522] Location in patent:supporting information
105-53-3
809 suppliers
$5.00/25g
104-84-7
235 suppliers
$21.00/5g
14111-33-2
23 suppliers
$244.00/500mg
123-11-5
906 suppliers
$10.00/10g
105-53-3
809 suppliers
$5.00/25g
14111-33-2
23 suppliers
$244.00/500mg
![Naphtho[1,8-ef]-1,4-dithiepin-2,2(3H)-dicarboxylic acid, 3-(4-methylphenyl)-, 2,2-diethyl ester](/CAS/20211123/GIF/181023-30-3.gif)
![2H-Naphtho[1,8-de]-1,3-dithiinium, 1-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-2-(4-methylphenyl)-, inner salt](/CAS/20211123/GIF/172845-78-2.gif)