[(difluoromethyl)thio]benzene synthesis
- Product Name:[(difluoromethyl)thio]benzene
- CAS Number:1535-67-7
- Molecular formula:C7H6F2S
- Molecular Weight:160.18
Yield: 80%
Reaction Conditions:
with N-benzyl-N,N,N-triethylammonium chloride in water at 60; for 12 h;
Steps:
1
330 g of a 40% aqueous solution of sodium thiophenolate, adding 0.3 g of benzyltriethylammonium chloride, and heating to 60 degrees, after stabilization,The reaction of chlorodifluoromethane was started, the absorption was very fast, the exotherm was obvious, and after 12 hours of reaction,Sampling analysis determined that the conversion of thiophenol was complete.After cooling, the lower liquid product is separated, washed with water, washed with saturated brine, dried and rectified to obtain 128 g, the yield is 80%, and the purity is over 98%.
References:
Beijing Aidewang Science And Technology Co., Ltd.;Zhou Weihua CN108341759, 2018, A Location in patent:Paragraph 0024
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![[[difluoro(triMethylsilyl)Methyl]thio]-Benzene](/CAS/GIF/536975-49-2.gif)
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