Dimethyl β,β'-(2-phenylethylamino)dipropionate synthesis
- Product Name:Dimethyl β,β'-(2-phenylethylamino)dipropionate
- CAS Number:38129-46-3
- Molecular formula:C16H23NO4
- Molecular Weight:293.36
Yield:38129-46-3 98.5%
Reaction Conditions:
in methanol; for 8.5 h;Cooling with ice;Reflux;
Steps:
1
Methyl acrylate (688.7 g, 8.0 mol)And anhydrous methanol (480 ml) were mixed and stirred for 30 min. Add β-phenylethylamine under ice bath (2) (387.8 g, 3.2 mol) and anhydrous methanol (320 ml) control the internal temperature does not exceed 40 ° C, dropping finished, heating to reflux stirring reaction 8h. The mixture was cooled to room temperature and methanol and excess methyl acrylate were recovered under reduced pressure to give a pale yellow oily liquid N, N-bis (β-methoxycarbonylethyl) phenethylamine (III) (926.0 g, yield 98.5%).
References:
CN102249986,2016,B Location in patent:Paragraph 0023-0025
