Dimethyl methylmalonate synthesis
- Product Name:Dimethyl methylmalonate
- CAS Number:609-02-9
- Molecular formula:C6H10O4
- Molecular Weight:146.14
Yield:609-02-9 94.79%
Reaction Conditions:
with sulfuric acid in toluene at 110 - 120;
Steps:
1 Synthesis of D, 2'-methylmalonic acid dimethyl ester
To a four-necked flask was added 2-methylmalononitrile (89.09 g, 1 mol)Methanol (64.08 g, 2 mol) and 150 mL toluene were added dropwise with concentrated sulfuric acid (200.00 g, 2 mol).After the drop is completed, the temperature is raised to 110 to 120 ° C for 9 to 10 h. Add 60 mL of water, after separation with toluene extraction (20 mLX3), dried over anhydrous magnesium sulfate,After filtration, the solvent was removed in vacuo to give 138.53 g of dimethyl 2-methylmalonate, boiling point: 68 to 70 ° C (10 mmHg) in a yield of 94.79 , M1R (300 MHz, CDCI3): 1.43 (d, J = 7.3 Hz, 3H, CH3), 3.46 (q, J = 7.3 Hz, 1 Hz), 3.74 (s, 6 Hz, CH3)
References:
Hebei Chengxin Jiutian Pharmaceutical And Chemical Co., Ltd.;Liu Shaohua;Shi Hui;Wang Jinhua;Guo Yayun;Wang Jinjin;Dong Pu;Cheng Lihua;Peng Yanli CN105061209, 2017, B Location in patent:Paragraph 0043-0045
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