DL-Menthol synthesis
- Product Name:DL-Menthol
- CAS Number:89-78-1
- Molecular formula:C10H20O
- Molecular Weight:156.27
89-79-2
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89-78-1
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10458-14-7
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Yield:-
Reaction Conditions:
with [Ru(PnOct3)4(H)2] in o-xylene at 130; under 375.038 Torr; for 12 h;Inert atmosphere;Autoclave;Reagent/catalyst;Temperature;Solvent;
Steps:
1 Comparative Example 1 (CN 104603095 Preparation Example 4)
Under inert conditions, 404 mg of [Ru (PnOct3) 4 (H) 2],3.6g of isopulegol and 10ml of o-xylene (anhydrous) were weighed into a 50ml glass autoclave.The reaction mixture was then stirred at an oil bath temperature of 130 ° C under autogenous pressure (0.5 bar positive pressure) for 12 hours.After the reaction, the conversion and yield (area%) of menthone (sum of isomers) were determined by gas chromatography.The conversion of isopulegol was 64.5%, and the selectivity of menthol (65.8% (-)-menthol, 34.2% (+)-isomenthol isomer mixture) was 46.3%.Selectivity of secondary components: menthol 30.2%, isopupleone 14.4%, total selectivity (menthol + menthol + isopupleone) 90.9%.
References:
Wanhua Chemical Group Co., Ltd.;Wang Yaxin;Wang Lianfang;Dong Jing;Li Wenbin;Sun Qikui;Chi Sensen;Cao Na;Cheng Ying;Wang Wen CN110922316, 2020, A Location in patent:Paragraph 0093-0094
89-83-8
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89-78-1
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