Domperidone Impurity 13 synthesis
- Product Name:Domperidone Impurity 13
- CAS Number:87120-77-2
- Molecular formula:C14H21N3O2
- Molecular Weight:263.34
![ethyl 4-[(2-nitrophenyl)amino]piperidine-1-carboxylate](/CAS/GIF/85443-52-3.gif)
85443-52-3
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87120-77-2
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Yield:87120-77-2 77%
Reaction Conditions:
palladium-carbon in methanol;
Steps:
7.2 7.2
7.2 4-(2-Nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester (from step 1 above) was dissolved in methanol then hydrogenated over 10% Pd/C (balloon pressure). The hydrogenation was run until the yellow color turned colorless. It was filtered through a celite pad, and the filtrated evaporated to a reddish brown residue. The residue was triturated with 1% ethyl acetate in hexanes and the solid collected by filtration to give 4-(2-amino-phenylamino)-piperidine-1-carboxylic acid ethyl ester (2.02 g; 77%, 2 steps). 1H NMR (CDCl3) δ1.27 (t, 3H, J=7.2), 1.4 (m, 2H), 2.05 (m, 2H), 3.0 (m, 2H), 3.4 (m, 4H), 4.1 (m, 4H), 6.7 (m, 4H)
References:
US2003/171360,2003,A1
1493-27-2
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87120-77-2
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58859-46-4
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$13.00/5g
87120-77-2
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