Sulfometuron-methyl synthesis
- Product Name:Sulfometuron-methyl
- CAS Number:74222-97-2
- Molecular formula:C15H16N4O5S
- Molecular Weight:364.38
767-15-7
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26638-43-7
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$7.00/250mg
74222-97-2
170 suppliers
$98.00/25mg
Yield:74222-97-2 98%
Reaction Conditions:
in acetonitrile
Steps:
1 Preparation of 2-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester
EXAMPLE 1 Preparation of 2-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester A slurry of 7.0 grams (0.057 moles) of 4,6-dimethyl-2-pyrimidinamine, 6.0 grams (0.092 moles) sodium cyanate, and 13.5 grams (0.057 moles) 2-carbomethoxybenzenesulfonyl chloride in 60 ml acetonitrile was stirred 1 hour at reflux (81°). The reaction was diluted with 60 ml water, allowed to cool to room temperature and filtered. The solid was washed with 20 ml water and dried. There was obtained 16.0 grams (77.0% of theory) of the title compound. The product was 98% pure as assayed by high pressure liquid chromatography. The m.p. and IR spectrum of the title compound were identical to those of an authentic sample prepared as described in U.S. Pat. No. 4,394,506.
References:
E. I. Du Pont de Nemours and Company US4546179, 1985, A
![Benzoic acid, 2-[[(methoxycarbonyl)amino]sulfonyl]-, methyl ester](/CAS/20180601/GIF/67359-63-1.gif)
767-15-7
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$5.00/1g
74222-95-0
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74222-97-2
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$98.00/25mg
81-07-2
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$13.98/25G
74222-97-2
170 suppliers
$98.00/25mg