(E)-Methyl 3-(3,4-difluorophenyl)acrylate synthesis
- Product Name:(E)-Methyl 3-(3,4-difluorophenyl)acrylate
- CAS Number:218430-47-8
- Molecular formula:C10H8F2O2
- Molecular Weight:198.17
67-56-1
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112897-97-9
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$10.00/1g
218430-47-8
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$45.00/10mg
Yield:218430-47-8 100%
Reaction Conditions:
with sulfuric acid for 24 h;Reflux;
Steps:
General procedure for the synthesis of compounds 9-12 and 21-29
General procedure: After dissolving the carboxylic acid in the alcohol, three drops of H2SO4 95% were added to the solution and the mixture was refluxed for 24 h. The solvent was evaporated under reduced pressure and water was added to the crude mixture. The pH of the aqueous layer was adjusted to 7 adding drops of a saturated solution of NaHCO3 and brine was added in the mixture. The aqueous layer was extracted three times with ethyl acetate; the organic layer was dried over Na2SO4 and the solvent was evaporated under reduced pressure yielding the final compound. Further purification step was made when it was necessary.
References:
Allegretta, Giuseppe;Weidel, Elisabeth;Empting, Martin;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2015,vol. 90,p. 351 - 359]
34036-07-2
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21204-67-1
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218430-47-8
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$45.00/10mg
112897-97-9
190 suppliers
$10.00/1g
218430-47-8
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$45.00/10mg
64248-58-4
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$14.00/5g
292638-85-8
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218430-47-8
18 suppliers
$45.00/10mg
77-78-1
315 suppliers
$22.00/25g
112897-97-9
190 suppliers
$10.00/1g
218430-47-8
18 suppliers
$45.00/10mg