ETHYL 2-CHLOROBENZOYLFORMATE synthesis
- Product Name:ETHYL 2-CHLOROBENZOYLFORMATE
- CAS Number:62123-75-5
- Molecular formula:C10H9ClO3
- Molecular Weight:212.63
1603-79-8
231 suppliers
$7.00/5g
62123-75-5
37 suppliers
$160.41/0.5g
Yield:62123-75-5 63%
Reaction Conditions:
with 2-chlorocyclopentane-1,3-dione;palladium diacetate;(2,2,2-trifluoroacetyl)oxysilver;glacial acetic acid;3,5-ditrifluoromethylaniline;trifluoroacetic acid at 100; for 24 h;Sealed tube;
Steps:
General Procedure II
General procedure: A sealed tube with magnetic stir bar was charged with NCS (40 mg, 0.3 mmol), Pd(OAc)2 (0.02 mmol) in air, followed by HFIP:AcOH (2 mL, 9:1), α-keto esters 1 (0.2 mmol), T5 (9.1 mg, 0.04 mmol) and TFA (136.8 mg, 1.2 mmol). The reaction mixture was stirred at 100 for 24 hours. Upon completion, the reaction mixture was quenched by sat. NaHCO3 (aq) (10 mL), and extracted with CH2Cl2 for 3 times. The combined organic layers were washed with water (15 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude residue was purified by column chromatography on silica gel using petroleum ether/EtOAc as eluent to afford the desired products.
References:
Wang, Jian;Wu, Yongdi;Xu, Wengang;Lu, Xuelian;Wang, Yunfang;Liu, Guangyuan;Sun, Bing;Zhou, Yirong;Zhang, Fang-Lin [Tetrahedron,2022,vol. 123,art. no. 132980] Location in patent:supporting information
3900-89-8
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$6.00/1g
623-49-4
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$10.60/1gm:
62123-75-5
37 suppliers
$160.41/0.5g
64-17-5
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$10.00/50g
40018-25-5
209 suppliers
$9.00/1g
62123-75-5
37 suppliers
$160.41/0.5g
64-17-5
891 suppliers
$10.00/50g
26118-14-9
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$45.00/10mg
62123-75-5
37 suppliers
$160.41/0.5g
19112-35-7
99 suppliers
$16.00/1g
62123-75-5
37 suppliers
$160.41/0.5g