一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Ethyl 3-broMo-5-chloroisonicotinate
1214387-79-7

Ethyl 3-broMo-5-chloroisonicotinate synthesis

1synthesis methods
-

Yield:1214387-79-7 85%

Reaction Conditions:

Stage #1: 3-bromo-5-chloropyridinewith lithium diisopropyl amide in tetrahydrofuran;n-heptane;ethylbenzene at -78; for 0.75 h;Inert atmosphere;
Stage #2: chloroformic acid ethyl ester in tetrahydrofuran;n-heptane;ethylbenzene; for 0.583333 h;
Stage #3: with sodium hydrogencarbonate in tetrahydrofuran;n-heptane;ethylbenzene;Product distribution / selectivity;

Steps:

102; 103; 147

To a solution of LDA (2 M solution in THF/heptane/ethylbenzene, 2.78 g, 12.97 mL, 25.95 mmol) in anhydrous THF (20 mL) under nitrogen atmosphere cooled to -78°C was added a solution of the 3-bromo-5-chloropyridine (5.0 g, 25.98 mmol) in anhydrous THF (40 mL) at -78°C. The reaction mixture was allowed to stir at the same temperature for 45 minutes. Then, a solution of chloro(ethoxy)methanone (28.19 g, 259.7 mmol) was added slowly over 15 minutes. After stirring for 20 minutes, the reaction mixture was quenched with saturated NaHCO3 solution. The reaction mixture was extracted into ethyl acetate (3 x 100 mL), and the combined organic layer was washed with water and brine. The organic layer was separated, dried over anhydrous sodium sulfate, and filtered. The filtrate was evaporated, and the residue was purified through CombiFlash using 0-10% ethyl acetate in hexane to provide ethyl 3-bromo-5-chloropyridine-4-carboxylate as a pale yellow oil (5.84 g, 85% yield); 1H NMR (400 MHz, DMSO-J6): δ 1.35 (t, 3H), 4.45 (q, 2H), 8.82 (s, IH), 8.87 (s, IH); M+ 265.5.

References:

WO2010/132999,2010,A1 Location in patent:Page/Page column 161; 163; 212

Ethyl 3-broMo-5-chloroisonicotinate Related Search:

锡林浩特市| 靖安县| 巴马| 桑植县| 盐亭县| 长治市| 伊吾县| 黄陵县| 都匀市| 蒲城县| 屏山县| 时尚| 志丹县| 山丹县| 龙海市| 乐陵市| 呼图壁县| 聂拉木县| 贵溪市| 嵊泗县| 固镇县| 峨山| 海宁市| 和顺县| 和平区| 青阳县| 浑源县| 黎平县| 梅河口市| 远安县| 烟台市| 农安县| 木里| 石嘴山市| 聊城市| 黄骅市| 巴彦淖尔市| 行唐县| 沾化县| 鄂托克旗| 沁水县|