ChemicalBook CAS DataBase List Ethyl 3-bromo-5-nitrobenzoate

Ethyl 3-bromo-5-nitrobenzoate synthesis

4synthesis methods

Product Name:Ethyl 3-bromo-5-nitrobenzoate
CAS Number:690260-94-7
Molecular formula:C9H8BrNO4
Molecular Weight:274.07

64-17-5

6307-83-1

690260-94-7

Add 3-bromo-5-nitrobenzoic acid (25 g, 101.6 mmol) and anhydrous ethanol (200 mL) to a 500 mL round bottom flask. With stirring at 0 °C, sulfoxide chloride (15 mL) was added slowly and dropwise. The reaction mixture was warmed to 80 °C with continuous stirring for 4 hours. Upon completion of the reaction, the reaction was quenched by the addition of 50 mL of water. The reaction mixture was extracted with dichloromethane (3 x 50 mL), the organic layers were combined and concentrated under reduced pressure. The concentrated residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether as eluent (gradient elution, 1:20 to 1:10). Ethyl 3-bromo-5-nitrobenzoate 27.5 g (99% yield) was obtained as a white solid.

64-17-5 Synthesis

64-17-5
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$10.00/50g

6307-83-1 Synthesis

6307-83-1
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$5.00/250mg

690260-94-7
71 suppliers
$17.00/250mg

Yield:690260-94-7 99%

Reaction Conditions:

with thionyl chloride at 0 - 80;

Steps:

1 Step 1: Ethyl 3-bromo-5-nitrobenzoate

Into a 500-mL round-bottom flask, was placed 3-bromo-5-nitrobenzoic acid (25 g, 101.6 mmol), EtOH (200 mL). This was followed by the addition of SOCl₂ (15 mL) dropwise with stirring at 0^oC. The resulting solution was stirred for 4 h at 80^oC and then was quenched by the addition of 50 mL water. The resulting solution was extracted with 3x50 mL of DCM and the organic layers combined and concentrated under vacuum. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1:20 to 1:10). This resulted in 27.5 g (99%) of the title compound as a white solid.

References:

WO2017/184623,2017,A1 Location in patent:Page/Page column 127

64-17-5 Synthesis

64-17-5
863 suppliers
$10.00/50g