Ethyl 4-acetylbutyrate synthesis
- Product Name:Ethyl 4-acetylbutyrate
- CAS Number:13984-57-1
- Molecular formula:C8H14O3
- Molecular Weight:158.2
67-64-1
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140-88-5
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13984-57-1
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Yield:13984-57-1 34%
Reaction Conditions:
with Potassium phosphate, dibasic at 60; for 6 h;Michael Addition;
Steps:
2 Example 2
Put 58g (1mol) acetone and 1.74g (10mmol) K2HPO4 in a dry three-necked flask equipped with a thermometer and a reflux condenser, then slowly add 10g (0.1mol) ethyl acrylate (3h dripping), at 60 ° C The reaction was carried out for 3 hours; after the reaction, the remaining unreacted acetone and methyl acrylate were distilled off from the reaction solution at 80° C. to obtain 9.22 g of ethyl 5-oxohexanoate with a yield of 34% and a selectivity of 90%.
References:
CN114516796,2022,A Location in patent:Paragraph 0031-0032
39495-82-4
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13984-57-1
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34495-74-4
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13984-57-1
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75-16-1
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13984-57-1
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13984-57-1
121 suppliers
$37.79/5g