一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Finerenone
1050477-31-0

Finerenone synthesis

2synthesis methods
Synthesis scheme of finerenone: Firstly, benzaldehyde 20.1 was condensed with acetoacetamide under Knoevenagel condensation conditions to give high yield of ketone 20.2 of undetermined structure.Meanwhile, pyridinyl chloride 20.3 was treated at high temperature with strong alkali conditions followed by treatment with strong acid at low temperature to give filterable pyridinone solid 20.4.
Addition of 20.2 to a heated isobutanol solution of 20.4 resulted in a condensation-cyclisation reaction to give the nitrogen-containing heterocyclic compound 20.5 in good yield. The conversion of the pyridone to the corresponding ether was achieved by treating the pyridone with 1,1,1-triethoxyethane under acidic conditions. Some of the synthetic methods for fenaridones were carried out by chromatographic separation of the racemate 20.6, while a recent patent reports a classical splitting using tartaric acid derived salts. In one example, 20.6 was reacted with p-toluoyl-d-tartaric acid in a mixture of ethanol and water to give the target enantiomer in 78% enantiomeric excess, which was purified to 99% enantiomeric excess by re-suspension in ethanol and water to ultimately give 20.7 in about 41% yield. Adjusting the pH in water and ethanol with sodium carbonate gave the free base of fenaridone (20) in 97% yield.
Synthesis of Finerenone
4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

1050477-27-4
83 suppliers
inquiry

isopropyl isocyanide dichloride

29119-58-2
0 suppliers
inquiry

-

Yield:29119-58-2 80%

Reaction Conditions:

Stage #1: 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide in 5,5-dimethyl-1,3-cyclohexadiene; for 8 h;Reflux;
Stage #2: with O,O'-dibenzoyl-D-tartaric acid in lithium hydroxide monohydrate at 30; for 4 h;Reflux;Solvent;

Steps:

1.6; 2.7; 3.7 (6) Synthesis of compound 6:

The solvent xylene was added to the reaction flask, 70 g (0.185 mol) of compound 5 was added, 30 g of catalyst was added, and the mixture was refluxed and stirred for 8 h. Target configuration measured by HPLC: non-target configuration = 84:16, ending transconfiguration. Filtration, the mother liquor was spin-dried to obtain the crude product, 150g of ethanol was added, 50g of water was added, after stirring and dissolving, 58.4g (0.155mol) D-dibenzoyltartaric acid was added, heated to reflux for 3h, cooled to 30°C, stirred for 1h and filtered to obtain The crude product was added to water, 10% sodium phosphate solution was added to adjust pH=7.5, stirred for 0.5 h to precipitate, filtered to obtain the crude product, and recrystallized with 200 g of ethanol to obtain 56 g of feneridone bulk drug with a yield of 80%.

References:

CN114605410,2022,A Location in patent:Paragraph 0046; 0064-0066; 0067; 0076-0077; 0087; 0091-0092

乳山市| 溆浦县| 随州市| 蛟河市| 冕宁县| 湘潭县| 屏东市| 兰考县| 常州市| 衡水市| 会宁县| 临邑县| 津市市| 凤翔县| 措勤县| 闽清县| 南岸区| 麻阳| 彭水| 定西市| 灵山县| 焦作市| 邢台市| 正定县| 乐清市| 永修县| 太仓市| 碌曲县| 郧西县| 中山市| 万山特区| 肇东市| 永川市| 景宁| 彭阳县| 开阳县| 蛟河市| 赫章县| 丹阳市| 晋宁县| 铁岭市|