Fingolimod Impurity 8 synthesis
- Product Name:Fingolimod Impurity 8
- CAS Number:162358-96-5
- Molecular formula:C16H25I
- Molecular Weight:344.27
629-04-9
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Yield:-
Steps:
Multi-step reaction with 9 steps
1.1: Mg / tetrahydrofuran / 1 h / 40 °C
1.2: 49 percent / tetrahydrofuran / 1 h / 20 °C
2.1: 82 percent / P2O5 / benzene / 2 h / Heating
3.1: Mg / tetrahydrofuran / 0.5 h / 50 °C
3.2: 88 percent / tetrahydrofuran / 15 h / 20 °C
4.1: 82 percent / H2 / 5percent Pd/C / ethanol / 4 h
5.1: Triton B / methanol; dioxane / 2 h / 80 °C
6.1: HCl / 0.5 h / 20 °C
7.1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
8.1: Et3N / CH2Cl2 / 1 h / 20 °C
9.1: NaI / butan-2-one / 2 h / Heating
References:
Kiuchi, Masatoshi;Adachi, Kunitomo;Kohara, Toshiyuki;Minoguchi, Masanori;Hanano, Tokushi;Aoki, Yoshiyuki;Mishina, Tadashi;Arita, Masafumi;Nakao, Noriyoshi;Ohtsuki, Makio;Hoshino, Yukio;Teshima, Koji;Chiba, Kenji;Sasaki, Shigeo;Fujita, Tetsuro [Journal of Medicinal Chemistry,2000,vol. 43,# 15,p. 2946 - 2961]
6630-33-7
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