一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Fluoxymesterone
76-43-7

Fluoxymesterone synthesis

1synthesis methods
Fluoxymesterone, 9-fluoro-11β,17β-dihydroxy-17α-methylandrost- 4-en-3-one (29.3.8), is made from 11β-hydroxy-4-androsten-3,17-dione, which is reacted with pyrrolidine to give a dieneamine (29.3.4). This undergoes a reaction with methylmagnesiumiodide, which after hydrolysis forms 11β,17β-dihydroxy-17α-methylandrost- 4-en-3-one (29.3.5). Dehydration of this compound by selective tosylation of the secondary hydroxyl group at C11 using p-toluenesulfonyl chloride and subsequent reaction with a base gives the diene (29.3.6), and the double bond at C9–C11 is transformed to an epoxide (29.3.7) by subsequent reaction with N-bromoacetamide in a wet solvent (source of HOBr), and a base. Further reaction with hydrogen fluoride results in an opening of the epoxide ring and the formation of the desired fluoxymesterone (29.3.8).

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: methanol; aq. NaOH solution
2: CH2Cl2; water; HF

References:

Herr et al. [Journal of the American Chemical Society,1956,vol. 78,p. 500]

Fluoxymesterone Related Search:

白朗县| 新余市| 永定县| 天峨县| 鲁甸县| 昌图县| 庆阳市| 内江市| 友谊县| 察隅县| 嫩江县| 申扎县| 南平市| 时尚| 广水市| 昆明市| 尤溪县| 泰安市| 彰化县| 赤水市| 天峻县| 前郭尔| 大名县| 丘北县| 固镇县| 丰台区| 绩溪县| 浦县| 望江县| 忻城县| 长白| 汶川县| 宜都市| 右玉县| 航空| 盈江县| 常熟市| 桃园县| 墨玉县| 宜川县| 繁昌县|