FMOC-DAB(BOC)-OH synthesis
- Product Name:FMOC-DAB(BOC)-OH
- CAS Number:125238-99-5
- Molecular formula:C24H28N2O6
- Molecular Weight:440.49
24424-99-5
161420-87-7
125238-99-5
The general procedure for the synthesis of N-Fmoc-N'-Boc-L-2,4-diaminobutyric acid from di-tert-butyl dicarbonate and Fmoc-L-2,4-diaminobutyric acid was as follows: 50 g (146.8 mmol) of Fmoc-L-2,4-diaminobutyric acid was suspended in 700 mL of a mixed solvent of acetone and water (1:1, v/v/v/v/v) at 0-10 °C. 38.4 g (176 mmol) of di-tert-butyl dicarbonate was slowly added. Subsequently, the pH of the reaction system was adjusted to 7.5-8 with 0.5 N NaOH solution.After 4 h of reaction, 56 g of N-fluorenylmethoxycarbonyl-N'-tert-butoxycarbonyl-L-2,4-diaminobutyric acid was obtained by the treatment in a yield of 86.62% and a purity of 99.4% by HPLC. The structure of the product was confirmed by IR and NMR spectra as detailed in Figures 3 and 4 in the literature.
24424-99-5
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161420-87-7
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125238-99-5
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Yield:125238-99-5 86.62%
Reaction Conditions:
with sodium hydroxide in water;acetone at 0 - 10; pH=7.5 - 8; for 4 h;pH-value;
Steps:
4.b Embodiment 4
B. The suspension 50g146 . 8nmolFmoc-Dab-OH with 700 ml acetone: water = 1:in 1(v/v), in 0-10 °C add 38.4g176 . 1nmol (Boc)2O, 0.5NNaOH adjusting pH= 7.5-8, reaction 4 hours after Fmoc-Dab (Boc)-OH56g processing product, yield 86.62%, HPLC99 . 4%. The infrared, nuclear magnetic resonance confirmed correct structure, see Figure 3, Figure 4.
References:
CN105348147,2016,A Location in patent:Paragraph 0020
71989-20-3
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125238-99-5
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$9.00/250mg
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159530-17-3
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125238-99-5
259 suppliers
$9.00/250mg