ChemicalBook CAS DataBase List Folic acid

Folic acid synthesis

8synthesis methods

Product Name:Folic acid
CAS Number:59-30-3
Molecular formula:C19H19N7O6
Molecular Weight:441.4

921-03-9
171 suppliers
$185.00/1kg

4271-30-1 Synthesis

4271-30-1
393 suppliers
$6.00/1g

35011-47-3 Synthesis

2,4,5-Triamino-6-hydroxypyrimidine sulfate

35011-47-3
359 suppliers
$5.00/5g

59-30-3
1228 suppliers
$5.00/5g

Yield:59-30-3 83.2%

Reaction Conditions:

with disodium metabisulfite at 20 - 30; for 2 h;Ionic liquid;Temperature;

Steps:

1 Example 1

The reaction flask was charged with 100 g of N-p-aminobenzoylglutamic acid,120 g 2,4,5-triamino-6-hydroxypyrimidine sulfate,160 g of 1,1,3-trichloroacetone,140 g of sodium metabisulfite,100 g of 1-ethyl-3-methylimidazolium tetrafluoroborate ([emim] BF4)Stirring temperature 20 ~ 30 stirring reaction 2h,During the reaction with sodium hydroxide to adjust the system pH 3.0 ~ 3.5,After the reaction is stopped, the mixture is stirred, filtered and the crude acid is obtained.The resulting crude folic acid and 4.5 L of purified water were added to the reaction flask and heated to 80 to 90 ° C with stirring. Then,Sodium chloride solution (2N) to adjust the system pH to 8 ~ 9, add 15g activated carbon stirring stirring for 30 minutes, hot filter. filtrateTemperature control 80 ~ 90 , adding dilute hydrochloric acid (2N) adjusted to pH 3.0 ~ 3.5, slowly cool to room temperature, filter, filter cake placed in the bakeBox temperature control 60 ~ 65 vacuum drying 5h, folic acid pure 138g, yield 83.2%, HPLC purity 99.7%, which miscellaneousQuality butterfly content of 0.09%.

References:

CN106432241,2017,A Location in patent:Paragraph 0023; 0024; 0025; 0026; 0027; 0028; 0029-0046

918-00-3 Synthesis