Fronepidil synthesis
- Product Name:Fronepidil
- CAS Number:79700-63-3
- Molecular formula:C21H31NO2
- Molecular Weight:329.481
127-66-2
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$11.00/1g
56-37-1
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$5.00/100g
![1-[2-chloro-3-(2-methylpropoxy)propyl]pyrrolidine](/CAS/GIF/49571-02-0.gif)
49571-02-0
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79700-63-3
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Yield:-
Reaction Conditions:
with sodium hydroxide in water;
Steps:
2 1-(1-methyl-1-phenyl-2-propynyloxy)-2-(N-pyrrolidinyl)-3-isobutoxy propane
EXAMPLE 2 1-(1-methyl-1-phenyl-2-propynyloxy)-2-(N-pyrrolidinyl)-3-isobutoxy propane In a corresponding manner as described in the previous example 6 g of the liquid product of the heading were obtained by refluxing for 5 hours a mixture constituted by 14.6 g of 2-phenyl-3-butyne-2-ol, 10 g of sodium hydroxide in 10 ml of water, 1,1 g of benzyl triethylammonium chloride and 11 g of 1-pyrrolidinyl-2-chloro-3-isobutoxy propane. BP0,5 =143°-145° C.; nD20 =1.502. The liquid base thus obtained was converted into the hydrochloride salt. Melting point HCl salt: 154° C. Elemental analysis:
References:
US4430332,1984,A