3,4,5-Trimethoxy benzoic acid synthesis
- Product Name:3,4,5-Trimethoxy benzoic acid
- CAS Number:118-41-2
- Molecular formula:C10H12O5
- Molecular Weight:212.2
1916-07-0
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118-41-2
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Yield:118-41-2 100%
Reaction Conditions:
with sodium hydroxide in ethanol at 50; for 2 h;
Steps:
3,4,5-trimethoxybenzoic acid (c-1)
To a stirred solution of methyl 3,4,5-trimethoxybenzoate(22.6 g, 0.1 mol) in 100mL of ethanol, a solution of 0.8mol/LNaOH (250mL) was added dropwise at room temperature.The reaction mixture was stirred at 50 °C for 2 h. Aftercooling to room temperature, the reaction mixture was carefullyacidified to pH 2~3 by adding concentrated hydrochloricacid under an ice-water bath. The precipitate was collected byfiltration, washed quickly with cold EtOH-H2O (3: 2), anddried at room temperature under high vacuum to give an3,4,5-trimethoxybenzoic acid c-1 (21.2 g, 100%).
References:
Chen, Dan;Niu, Xiaochen;Wang, Junfei;Zhang, Hongwei;Zhang, Wei;Zhao, Jianchun [Medicinal Chemistry Research,2022,vol. 31,# 5,p. 794 - 804]
1136-86-3
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118-41-2
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$14.00/5g
86-81-7
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$16.26/10gm:
118-41-2
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$14.00/5g
36266-40-7
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118-41-2
584 suppliers
$14.00/5g