Glycine, N-(2-hydroxyethyl)-, ethyl ester synthesis
- Product Name:Glycine, N-(2-hydroxyethyl)-, ethyl ester
- CAS Number:214709-53-2
- Molecular formula:C6H13NO3
- Molecular Weight:147.17
Yield:214709-53-2 41%
Reaction Conditions:
with potassium carbonate in acetonitrile at 0; for 2 h;
Steps:
8 Ethyl (2-hydroxyethyl)glycinate
To a 0°C solution of 2-aminoethanol (32.8 mmol) and K2CO3 (164 mmol) in 80 mL acetonitrile was added a solution of ethyl bromoacetate (32.8 mmol) in 2 ml_ of acetonitrile over a 1 h period. The solution was stirred for 1 h at 0 °C and filtered. The filtrate was concentrated in vacuo to give a residue which was subjected to flash column chromatography (0% to 10% MeOH in EtOAc) to yield the desired product in 41 %. (0387) Rf = 0.16 (5% MeOH in EtOAc); 1 H NMR (400 MHz, Chloroform-d): d = 5.48 (bs, 1 H), 4.71 (bs, 1 H), 4.15 (quart, 2H), 3.58 (s, 2H), 3.51 (m, 2H), 2.74 (m, 2H), 1.31 (t, 2H); (0388) UPLC-MS (ESI) m/z found 148.13 [M+H]+, required 148.10 [C6H14N03]+.
References:
WO2020/260597,2020,A1 Location in patent:Page/Page column 68
![Acetonitrile, 2-[(2-hydroxyethyl)amino]-](/CAS/20210305/GIF/54961-35-2.gif)
2002-24-6
229 suppliers
$5.00/100mg
105-36-2
346 suppliers
$5.00/5G
51992-82-6
0 suppliers
inquiry
214709-53-2
1 suppliers
inquiry