一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Guaiazulene
489-84-9

Guaiazulene synthesis

4synthesis methods
Guaiazulene is a dark blue crystalline hydrocarbon,it is synthesised by 2,2'-[[2-[3,8-dimethyl-5-(1-methylethyl)-1-azulenyl]ethenylidene]bis(4,1-phenyleneoxy)]bis[N,N-dimethyl-Ethanamine and AZULENE,with hydrogenchloride in methanol;water;acetonitrile at 60.
-

Yield: 97% ， 58%

Reaction Conditions:

with hydrogenchloride in methanol;water;acetonitrile at 60; for 3 h;

Steps:

4.1.10. Reaction of 1,1-bis{4-[2-(dimethylamino)ethoxy]phenyl}-2-(3-guaiazulenyl)ethylene (13) with azulene (1)
To a solution of a commercially available 1 (5 mg, 39 μmol) in methanol (2 mL) was added a solution of 13 (20 mg, 36 μmol) in acetonitrile (3 mL). The mixture containing 36% hydrochloric acid (50 μL) was stirred at 60 °C for 3 h. After the reaction, distilled-water was added to the mixture and then the resulting products were extracted with dichloromethane (10 mL×3). The extract was washed with distilled-water, dried (MgSO4), and evaporated in vacuo. The residue thus obtained was carefully separated by silica gel column chromatography with methanol-dichloromethane (30:70, v/v) as an eluant. Guaiazulene1 (10) (7 mg, 35 μmol, 97% yield) and a new compound 2-(azulen-1-yl)-1,1-bis{4-[2-(dimethylamino)ethoxy]phenyl}ethylene (18) (10 mg, 21 μmol, 58% yield) were isolated. The structure of the product 10 was identified on the basis of silica gel TLC analysis and EIMS and 1H NMR spectral data. Along with the above products, this reaction gave a chromatographically inseparable mixture of dark brown-colored polar resinous substances.

References:

Takekuma, Shin-Ichi;Kaibara, Masamichi;Minematsu, Toshie;Takekuma, Hideko [Tetrahedron,2011,vol. 67,# 26,p. 4780 - 4792] Location in patent:experimental part

Guaiazulene Related Search:

清丰县| 阳新县| 衡水市| 镇安县| 开封市| 扎囊县| 新闻| 唐山市| 登封市| 元朗区| 江油市| 镇雄县| 道孚县| 尼木县| 崇信县| 托克逊县| 思茅市| 锡林浩特市| 田阳县| 合山市| 行唐县| 江孜县| 象州县| 湖州市| 方城县| 海淀区| 青神县| 项城市| 安顺市| 辽阳县| 贵定县| 齐河县| 加查县| 德阳市| 黄浦区| 得荣县| 南汇区| 镇坪县| 清流县| 东安县| 镇安县|