H-9 2HCL synthesis
- Product Name:H-9 2HCL
- CAS Number:84468-17-7
- Molecular formula:C11H13N3O2S
- Molecular Weight:251.3
107-15-3
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84468-17-7
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Yield:84468-17-7 89%
Reaction Conditions:
in chloroform at 20; for 1 h;
Steps:
2 Preparation 2; Isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide
Powdered isoquinoline-5-sulfonyl chloride hydrochloride (5.57 g, 21.1 mmol) is added in small portions to a stirred solution of ethylenediamine (45.0 mL, 673 MMOL) in CHC13 (400 ML) at ambient temperature under nitrogen. The resultant mixture is stirred for 1 hour. After filtration and concentration in vacuo, the crude product is chromatographed on silica (gradient 5-10% CH30H in CH2C12, then 0-16% 2M NH3/CH30H in CH2C12) to give 4.71 g (18.7 mmol, 89% yield) of the title compound. ESIMS: m/z 252 (M+H) +.
References:
WO2004/94386,2004,A1 Location in patent:Page 17
27655-40-9
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84468-17-7
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84468-15-5
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84468-17-7
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![Carbamic acid, [2-[(5-isoquinolinylsulfonyl)amino]ethyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/20180531/GIF/651309-72-7.gif)
651309-72-7
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84468-17-7
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$110.09/10mg
105627-79-0
151 suppliers
$20.00/100mg
84468-17-7
48 suppliers
$110.09/10mg