HEPTAFLUOROISOPROPYL METHYL ETHER synthesis
- Product Name:HEPTAFLUOROISOPROPYL METHYL ETHER
- CAS Number:22052-84-2
- Molecular formula:C4H3F7O
- Molecular Weight:200.05
Yield: 91%
Reaction Conditions:
cesium fluoride in Tetraethylene glycol dimethyl ether at 100; for 36 h;
Steps:
12 EXAMPLE 12; (CF3)2CFOCH3 synthesis
0.38 g of CsF in powder (2.5 mmoles) and 1.02 g of tetraglyme are introduced by dry-box in a 25 ml autoclave equipped with pressure transducer and magnetic anchor. After having removed the uncondensable products by a vacuum system, 15.6 mmoles of hexafluoroacetone and 16.7 mmoles of methylfluoroformate are condensed in the autoclave. The autoclave is put in an oil bath maintained at the temperature of 100°C. After 36 hours the heating is stopped and the autoclave content is transferred in a vacuum system. By a trap-to-trap distillation with traps maintained, respectively, at the temperatures of -78°C, -115°C and -196°C, 2.84 g of pure product are isolated in the trap at -115°C, with an alkylation yield with respect to the initial hexafluoroacetone of 91%. The selectivity is 100%.
References:
Solvay Solexis S.p.A. EP1462434, 2004, A1 Location in patent:Page 7
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