Hercynine synthesis
2synthesis methods
- Product Name:Hercynine
- CAS Number:534-30-5
- Molecular formula:C9H15N3O2
- Molecular Weight:197.24
A method for producing hercynine on an industrial scale comprises the steps of:
1. reacting L-histidine, in a polar solvent or a mixture of polar solvents, with a methylating agent, MeX, at room temperature under controlled pH conditions;
2. separ
Yield: 36%
Reaction Conditions:
Stage #1:N,N-dimethyl-L-histidine hydrochloride with ammonia in methanol;water; pH=9
Stage #2:methyl iodide in methanol;water at 20;
References:
Song, Heng;Leninger, Maureen;Lee, Norman;Liu, Pinghua [Organic Letters,2013,vol. 15,# 18,p. 4854 - 4857] Location in patent:supporting information
