Ibandronate sodium monohydrate synthesis
- Product Name:Ibandronate sodium monohydrate
- CAS Number:138926-19-9
- Molecular formula:C9H24NNaO8P2
- Molecular Weight:359.23
114084-78-5
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$78.00/100mg
138926-19-9
317 suppliers
$5.00/50mg
Yield:-
Reaction Conditions:
with sodium hydroxide in water; pH=4.3 - 4.4;Product distribution / selectivity;
Steps:
4; 5
Example 4 Ibandronic acid (10 g) is suspended in water (200 ml) and added with 1M NaOH to pH 4.3-4. 4. The resulting clear solution is filtered through a 0.22 micron filter, frozen to-40°C and lyophilized (< 100 mbar, 0-40°C), to give amorphous monosodium ibandronate with a water content of less than 2%. Example 5 Ibandronic acid (10 g) is suspended in water (200 ml) and added with 1M NaOH to pH 4.3-4. 4. The resulting clear solution is filtered through a 0. 22 micron filter and conveyed under pressure to a spray-drier (nozzle temperature = 180-200°C). Amorphous monosodium ibandronate identical to that of Example 1 is obtained.
References:
WO2005/63779,2005,A2 Location in patent:Page/Page column 6
1310-73-2
1512 suppliers
$14.00/25g
114084-78-5
147 suppliers
$78.00/100mg
138926-19-9
317 suppliers
$5.00/50mg
1310-73-2
1512 suppliers
$14.00/25g
138926-19-9
317 suppliers
$5.00/50mg
127-09-3
1186 suppliers
$8.00/100dtn(0.82g)
114084-78-5
147 suppliers
$78.00/100mg
138926-19-9
317 suppliers
$5.00/50mg