Iodoform synthesis
- Product Name:Iodoform
- CAS Number:75-47-8
- Molecular formula:CHI3
- Molecular Weight:393.73
109-73-9
466 suppliers
$9.00/1g
98-86-2
792 suppliers
$9.00/5g
75-47-8
249 suppliers
$19.00/25g
2782-40-3
29 suppliers
$470.00/1g
Yield:2782-40-3 85% ，75-47-8 30%
Reaction Conditions:
with tert.-butylhydroperoxide;iodine in water;Petroleum ether at 0; for 12 h;Reagent/catalyst;Solvent;
Steps:
General procedures for amides 3
General procedure: Methyl ketones (0.5mmol), ammines (2.0mmol), I2 (0.55mmol, 110mol%), TBHP (6.0equiv, 70% aqueous solution 401 uL), and 2.0mL of PE, were added to a tube under air. The reaction mixture was stirred at 0°C for 12h. The reaction mixture was quenched with saturated Na2S2O3 solution, extracted repeatedly with ethyl acetate, dried over Na2SO4. It was then removal of the organic solvent in vacuum and followed by flash silica gel column chromatographic purification afforded product with Petroleum/Ethyl acetate mixtures.
References:
Zhu, Chunyin;Wei, Wei;Du, Peng;Wan, Xiaobing [Tetrahedron,2014,vol. 70,# 51,p. 9615 - 9620]
507-25-5
89 suppliers
$60.00/500mg
75-47-8
249 suppliers
$19.00/25g
67-64-1
0 suppliers
$17.30/10ml
75-47-8
249 suppliers
$19.00/25g
64-17-5
856 suppliers
$10.00/50g
75-47-8
249 suppliers
$19.00/25g