一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Kryptofix 222
23978-09-8

Kryptofix 222 synthesis

5synthesis methods
-

Yield:23978-09-8 61.54%

Reaction Conditions:

Stage #1:triethylene glycol di-(p-toluenesulfonate) with sodium carbonate in acetonitrile at 40; for 0.166667 h;
Stage #2:3,6-dioxa-1,8-diaminooctane in acetonitrile at 90; for 16 h;
Stage #3: with citric acid in ethanol;acetonitrile at 85; for 3 h;Reagent/catalyst;Temperature;

Steps:

1.2; 2.2; 3.2; 4.2; 5.2; 6.2 Step 2: Preparation of amino polyether (2.2.2)
First, 28.9 mM of triethylene glycol bis(p-toluenesulfonate) and 25 g of Na2C03 were dissolved in 375 mL of acetonitrile and stirred at 40 ° C for 10 min.Then, 13.5 mmol of 2,2'-(ethylenedioxy)bis(ethylamine) was added, and the mixture was heated to 90 ° C, refluxed for 16 hours, cooled and filtered to give a filtrate A.[0036] Finally, after the filtrate A was rotary evaporated, it was dissolved by adding 150 mL of ethanol.Add 20mL of 1.8mol/L citric acid solution, heat to 85 ° C, reflux for 3h,Filtrate B was obtained by filtration. Adjusting the pH of the filtrate B to about 10 with tetramethylammonium hydroxide.Wash three times with chloroform, then dry with 4A molecular sieve, after drying,Pour out the solution and evaporate to give a pale yellow crude product.The crude product was recrystallized from n-hexane.Get a white product 3.3g,That is, amino polyether (2.2.2).. The test results show that the prepared compound is an amino polyether (2.2.2After testing, the purity of amino polyether (2.2.2) is above 98%.The reaction cycle is 27h, and the total yield is 61.54%.Compared with the yield of the comparative example prepared aminopolyether (2.2.2) of 39.1%,It shows that the decomplexation with citric acid can improve the reaction yield.

References:

Jiangsu Atomic Medical Institute;Wang Hongyong;Han Guoqing;Zou Pei;Liu Yaling;Wu Jun;Wu Hao CN108822128, 2018, A Location in patent:Paragraph 0026; 0033-0036; 0038; 0039; 0045-0049; 0050; 0056

FullText

Kryptofix 222 Related Search:

司法| 布尔津县| 荥阳市| 莲花县| 承德县| 通山县| 荃湾区| 昭平县| 德昌县| 南城县| 都昌县| 信宜市| 孟村| 莱西市| 大新县| 泸水县| 宝鸡市| 黄陵县| 阳原县| 海淀区| 民乐县| 天气| 政和县| 庆元县| 鄢陵县| 饶平县| 牟定县| 兖州市| 宁波市| 湟源县| 布拖县| 南充市| 永修县| 江口县| 铁岭市| 江津市| 浮山县| 乐昌市| 金华市| 新兴县| 达孜县|