Lamotrigine Impurity 3 synthesis
- Product Name:Lamotrigine Impurity 3
- CAS Number:35022-44-7
- Molecular formula:C8H3Cl2NO
- Molecular Weight:200.02
33719-42-5
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Yield:-
Reaction Conditions:
with thionyl chloride
Steps:
1.b EXAMPLE 1b STR9
EXAMPLE 1b STR9 20.2 g (0.1 mole) of cyano-(3,4-dichlorophenyl)-(hydroxy)-methane are introduced at room temperature into 50 ml (81.9 g/0.69 mole) of thionyl chloride. The mixture is stirred at said temperature for 24 hours, the small amount of precipitate which is formed is filtered off with suction, and the reaction product is freed of excess thionyl chloride. The result is 19.4 g of an oily product. The GC content of 3,4-dichlorobenzoyl cyanide is 51.5%; the yield corresponds to 50.5% of theory. The product is worked up using high vacuum distillation (113° C. to 114° C./0.3 mbar). The resulting pure 3,4-dichlorobenzoyl cyanide has a melting point of 70° C. to 71° C.
References:
Bayer Aktiengesellschaft US4536353, 1985, A
3218-49-3
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35022-44-7
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