一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Loratadine Impurity 17
133330-72-0

Loratadine Impurity 17 synthesis

1synthesis methods
31251-41-9 Synthesis
8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

31251-41-9
250 suppliers
$128.00/5g

Loratadine Impurity 17

133330-72-0
21 suppliers
inquiry

-

Yield: 100%

Reaction Conditions:

Stage #1:8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one with sodium tetrahydroborate in methanol at 0 - 20; for 1 h;
Stage #2: with hydrogenchloride in methanol;water

Steps:

3.E
The title compound of Step D (700 mg) above was dissolved in MeOH (10 ml) and cooled to 00C. NaBH4 (95 mg) was added in one portion. The mixture was allowed to warm to RT and stirred for 1 h. The reaction was acidified with 1 N HCl and subsequently, brought to pH 12 with 1 N NaOH. The mixture was poured in water (100 ml) and extracted with CHCl3 (100 ml). The organic phase was dried over MgSO4 and concentrated affording the title compound (705 mg; 100 %).1HNMR δ (MeOD-dO 3.0-3,4 (m, 4H), 6.1(s, IH), 7.1.7.3 (m, 3H), 7.5-7.6 (m, 2H), 8.3:8.4 (m, IH)

References:

ALANTOS PHARMACEUTICALS, INC. WO2006/116157, 2006, A2 Location in patent:Page/Page column 56; 58

Loratadine Impurity 17 Related Search:

安西县| 化德县| 铁力市| 类乌齐县| 东辽县| 麦盖提县| 黎城县| 简阳市| 金溪县| 临海市| 广灵县| 晴隆县| 于都县| 永清县| 平昌县| 南和县| 镇康县| 凤台县| 奎屯市| 哈密市| 德清县| 澄迈县| 青铜峡市| 南昌市| 简阳市| 门源| 托克托县| 水富县| 聂荣县| 石阡县| 保德县| 霍林郭勒市| 义乌市| 句容市| 延庆县| 五峰| 洛南县| 油尖旺区| 鹰潭市| 伽师县| 郴州市|