ChemicalBook CAS DataBase List Maprotiline

Maprotiline synthesis

4synthesis methods

Product Name:Maprotiline
CAS Number:10262-69-8
Molecular formula:C20H23N
Molecular Weight:277.4

Maprotiline, N-methyl-9,10-ethanoanthracen-9(10H)-propylamine (7.1.22), is synthesized by a 42 cycloaddition reaction of 9-(3-methylaminopropyl)anthracene with ethylene [39–41].

Maprotiline is frequently referred to as a tetracyclic antidepressant. This “hybrid” drug, containing both elements of “classic tricyclic antidepressants” and protriptyline elements, is pharmacologically and clinically more similar to imipramine.

90-44-8 Synthesis

90-44-8
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10262-69-8
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: (i) KOtBu, tBuOH, (ii) aq. HCl
2: Zn, aq. NH₃
3: dimethylformamide / 170 °C
4: (COCl)2
6: LiAlH₄ / diethyl ether

References:

Wilhelm;Schmidt [Helvetica chimica acta,1969,vol. 52,# 6,p. 1385 - 1395]

FullText

N-Methyl-9,10-ethanoanthracene-9(10H)-propionamide

23716-34-9
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10262-69-8
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References

9,10-Ethanoanthracene-9(10H)-propionic acid

6812-49-3
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10262-69-8
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References

41034-83-7 Synthesis

41034-83-7
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10262-69-8
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References

Maprotiline Related Search:

Pirimiphos-methyl Methyl salicylate Methyl acetate Parathion-methyl

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Maprotiline synthesis

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