MEDROXYPROGESTERONE synthesis
- Product Name:MEDROXYPROGESTERONE
- CAS Number:520-85-4
- Molecular formula:C22H32O3
- Molecular Weight:344.49
71-58-9
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Yield:-
Reaction Conditions:
with water;sodium hydroxide in methanol for 5 h;Reflux;
Steps:
1 Hydrolysis of medroxyprogesterone acetate into medroxyprogesterone Medroxyprogesterone
To the stirred solution of medroxyprogesterone acetate (5g) in methanol (50 ml), 10 % aqueous sodium hydroxide solution was added (50 ml), and the reaction was refluxed. After completion of reaction as per TLC (after 5 h), methanol was evaporated, 100 ml of distilled water was added to the reaction mixture and its pH was made neutral slightly with 6N HC1. Further, aqueous portion was again extracted twice with ethyl acetate (200 ml). Combined ethyl acetate layer was first washed with ice cold water (400 ml), and then with brine water (400 ml). Ethyl acetate layer was dried over anhydrous sodium sulphate and finally evaporated on the rotary evaporator to afford medroxyprogesterone in 93% yield. Purified compound was characterized by high resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR). The HRMS and 1 H-NMR spectra of thus obtained medroxyprogesterone are shown in Figures 1 and 2 respectively. The mass spectral data were as follows:
References:
HAFEEZ, Kalak Abdul;PITTALA, Sandhya WO2020/245641, 2020, A1 Location in patent:Paragraph 00055
23706-51-6
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