METHYL 2,4-DIBROMOBUTYRATE synthesis
- Product Name:METHYL 2,4-DIBROMOBUTYRATE
- CAS Number:29547-04-4
- Molecular formula:C5H8Br2O2
- Molecular Weight:259.92
Yield:29547-04-4 890 g
Reaction Conditions:
at 0; for 0.5 h;Temperature;
Steps:
1.B; 2.B; 3.B (B) Synthesis of methyl 2,4-dibromobutanoate:
The reaction liquid system in the previous step was cooled and cooled to 0 °C.Add 350 ml of methanol at about 0 °C.After the completion of the dropwise addition, the reaction was carried out at 0 ° C for 30 min. Pour the reaction into 1.5 L of ice water.Extract once with 3 L methyl tert-butyl ether (MTBE).The organic phase was washed twice with 2 L of saturated brine.Dry filter, filter cake washed once with MTBE,Spin dry to 1050 g of light yellow liquid.The vacuum distillation was carried out at an external temperature of 110 ° C, 120 Pa, 80 ° C to obtain a methyl 2,4-dibromobutyrate product of 890 g (84%).
References:
CN110028441,2019,A Location in patent:Paragraph 0016; 0017; 0027; 0028; 0038; 0039
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