METHYL 2-([(E)-PHENYLMETHYLIDENE]AMINO)PROPANOATE synthesis
- Product Name:METHYL 2-([(E)-PHENYLMETHYLIDENE]AMINO)PROPANOATE
- CAS Number:120328-90-7
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
Yield:-
Reaction Conditions:
with magnesium sulfate;triethylamine in dichloromethane at 0 - 20; for 16 h;
Steps:
1.1 Methyl (E)-2-(benzylideneamino)propanoate (3)
To a stirred solution of methyl alaninate hydrochloride (1) (2 g, 14.388 mmol) in DCM (30 mL) at 0 °C was added magnesium sulphate (1.2 g, 10.028 mmol), Et3N (2.4 mL) and benzaldehyde (1.5 g, 14.326 mmol) and raised temperature to RT and stirred for 16 h. Reaction mixture filtered through celite pad and celite bed was washed with DCM. Organic layer washed with water (150 mL), extracted with DCM (2 x 150 mL), dried over anhydrous Na2SO4 and evaporated under reduced pressure to afford compound methyl (E)-2-(benzylideneamino)propanoate (3).
References:
WO2021/188620,2021,A1 Location in patent:Paragraph 00215; 00224
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