Methyl 3,4-dihydroxybenzoate synthesis
- Product Name:Methyl 3,4-dihydroxybenzoate
- CAS Number:2150-43-8
- Molecular formula:C8H8O4
- Molecular Weight:168.15
3943-74-6
355 suppliers
$5.00/100mg
2150-43-8
296 suppliers
$13.43/1gm:
Yield:2150-43-8 90%
Reaction Conditions:
with aluminium(III) iodide;N,N-dimethyl-formamide dimethyl acetal in acetonitrile at 80; for 18 h;Reagent/catalyst;Temperature;
Steps:
4-6; 3-4 Example 4 (Demethylation of methyl vanillate)
Add acetonitrile (40ml), aluminum triiodide (2.242g, 5.5mmol)) and N,N-dimethylformamide dimethyl acetal (0.894g, 7.5mmol) into a 100ml round bottom flask. After stirring for 15 min, methyl vanillate (0.911g, 5mmol) was added, and stirring was continued at 80°C for 18h. After the reaction was completed, it was quenched with 2M dilute hydrochloric acid (10ml), and then extracted three times with ethyl acetate (50ml). Phase, first washed with saturated sodium thiosulfate aqueous solution (10ml), then dried over anhydrous magnesium sulfate, filtered, the filtrate was removed with a rotary evaporator to remove the solvent, and the residue was passed through flash column chromatography (eluent is petroleum ether/ethyl acetate Ester=4:1, volume ratio) was purified to obtain 0.757 g of methyl 3,4-dihydroxybenzoate (white solid, yield 90%).
References:
Jingchu Institute Of Technology;Tian Juan;Yue Huaxin;Li Yijin;Sang Dayong CN111620764, 2020, A Location in patent:Paragraph 0041-0057
67-56-1
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$7.29/5ml-f
99-50-3
609 suppliers
$10.00/5g
2150-43-8
296 suppliers
$13.43/1gm:
6702-50-7
206 suppliers
$11.00/1g
2150-43-8
296 suppliers
$13.43/1gm:
6702-50-7
206 suppliers
$11.00/1g
99-50-3
609 suppliers
$10.00/5g
2150-43-8
296 suppliers
$13.43/1gm:
3943-74-6
355 suppliers
$5.00/100mg
99-50-3
609 suppliers
$10.00/5g
2150-43-8
296 suppliers
$13.43/1gm: