Methyl 3-(4-MethoxybenzylaMino)propanoate synthesis
- Product Name:Methyl 3-(4-MethoxybenzylaMino)propanoate
- CAS Number:55383-92-1
- Molecular formula:C12H17NO3
- Molecular Weight:223.27
Yield:55383-92-1 100%
Reaction Conditions:
in methanol at 0; for 15.5 h;
Steps:
30.I Step I
A solution of p-methoxybenzyl amine (690mg, 722μL, 8.01 mmol) in dry methanol (5 ml), under nitrogen was cooled to 0° and treated drpwise with a solution of metacrylate (951PL, 1. 0G, 7. 28MMOL) in MeOH (1.0 ml) added over 2 min. After 15. 5h the clear solution was distilled at atmospheric pressure to remove MeOH. The high boiling residue (> 170-) formed 3- (4-METHOXY- BENZYLAMINO)-PROPIONIC acid methyl ester ( 1.88g, Quantitative ) 1H (300MHz, CDCl30 1.78 (bs, 1H), 2.45 and 2.53 (T, J = 3. OHZ, 2H), 2.77 and 2.87 (t, J = 3. 0Hz, 2H), 3.46 and 3.67 (s, 3H), 3.64 and 3.73 (s, 3H), 3.88 (m, 2H), 6.78 and 6.85 (m, 2H), 7.17 and 7.23 (m, 2H).
References:
WO2004/52885,2004,A1 Location in patent:Page 130
