Methyl 3,5-difluoro-4-methoxybenzoate synthesis
2synthesis methods
- Product Name:Methyl 3,5-difluoro-4-methoxybenzoate
- CAS Number:329-45-3
- Molecular formula:C9H8F2O3
- Molecular Weight:202.15
Yield:329-45-3 95%
Reaction Conditions:
Stage #1: 3,5-difluoro-4-hydroxybenzoic acidwith potassium carbonate in N,N-dimethyl-formamide at 20;Inert atmosphere;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 20;Inert atmosphere;
References:
Grimster, Neil P.;Connelly, Stephen;Baranczak, Aleksandra;Dong, Jiajia;Krasnova, Larissa B.;Sharpless, K. Barry;Powers, Evan T.;Wilson, Ian A.;Kelly, Jeffery W. [Journal of the American Chemical Society,2013,vol. 135,# 15,p. 5656 - 5668] Location in patent:supporting information
