METHYL 3-ETHYL-4-HYDROXYBENZOATE synthesis
- Product Name:METHYL 3-ETHYL-4-HYDROXYBENZOATE
- CAS Number:22934-36-7
- Molecular formula:C10H12O3
- Molecular Weight:180.2
67-56-1
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Yield:22934-36-7 50%
Reaction Conditions:
with palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride;anhydrous potassium acetate at 70;
Steps:
1.1 Step 1 Synthesis of methyl 3-ethyl-4-hydroxyphenylacetate (II-1)
In the reaction flask, I-1 (40.0g, 0.2mol), Pd(dppf)Cl2(14.6g, 0.02mol), potassium acetate (58.8g, 0.6mol) and methanol (200.0mL) were added in sequence, and carbon monoxide was used. The balloons were replaced three times and stirred overnight at 70°C under a carbon monoxide atmosphere.After the reaction was completed, the solvent was evaporated under reduced pressure, added to water (100.0 mL), extracted with ethyl acetate (150.0 mL×3), the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain The crude product was purified by silica gel column [eluent: petroleum ether-ethyl acetate (1:2)], the eluent was collected, and the solvent was evaporated under reduced pressure to obtain yellow solid II-1 (18.0 g, yield: 50.0%) ).
References:
CN113912547,2022,A Location in patent:Paragraph 0126-0132
90-00-6
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22934-47-0
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1927-95-3
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22934-36-7
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