methyl 3-oxododecanoate synthesis
- Product Name:methyl 3-oxododecanoate
- CAS Number:76835-64-8
- Molecular formula:C13H24O3
- Molecular Weight:228.33
Yield:76835-64-8 96 %
Reaction Conditions:
Inert atmosphere;Reflux;
Steps:
General Procedure for the Methanolysis of the Meldrum 4a-b Acid Derivative (GP2)
General procedure: The meldrum 3a-c acid derivative (1.0 equiv.) was dissolved in excess methanol and the reaction flask was equipped with a reflux apparatus under an argon atmosphere. The reaction was heated at reflux for 2 hours, then the heating was stopped and the mixture allowed to cool spontaneously to room temperature and stirred overnight. The progress of the reaction was followed by TLC in an EtOAc/cyclohexane mixture at 1:1 and revealed in iodine. On completion, the solvent was removed under vacuum and the oily product was used raw in the following step.
References:
US2022/411397,2022,A1 Location in patent:Paragraph 0218-0220
38330-80-2
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112-13-0
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76835-64-8
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112-13-0
294 suppliers
$14.00/25g
76835-64-8
29 suppliers
inquiry
