Methyl 4-cyanobenzoate synthesis
- Product Name:Methyl 4-cyanobenzoate
- CAS Number:1129-35-7
- Molecular formula:C9H7NO2
- Molecular Weight:161.16
Yield:1129-35-7 100%
Reaction Conditions:
with monolith-SO3H in toluene at 80; for 24 h;Inert atmosphere;
Steps:
Methylation of Various Carboxylic Acids (Table 3):
General procedure: To atest tube were added the carboxylic acid (500 mol), monolith-SO3H (100 wt%), and toluene (0.5 mL). Then, MeOH (30.3 L,750 mol) and additional toluene (0.5 mL) were added. Thereaction mixture was stirred under an Ar atmosphere (balloon)at 80 °C for 24 h, then passed through a cotton filter to removemonolith-SO3H and washed with Et2O (15 mL). The filtratewas concentrated in vacuo. The residue was purified by silica gel flash column chromatography (n-hexane/Et2O) to give thecorresponding methyl ester, if necessary. The 1H and 13CNMRspectra of the product were identical to those in the literature.
References:
Ichihara, Shuta;Ishida, Moeka;Ito, Ryo;Kato, Ayumu;Monguchi, Yasunari;Nakamura, Shinji;Park, Kwihwan;Sajiki, Hironao;Takada, Hitoshi;Wakayama, Fumika;Yamada, Tsuyoshi;Yamada, Yutaro [Bulletin of the Chemical Society of Japan,2021,vol. 94,# 11,p. 2702 - 2710]
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