Methyl N-Boc-L-proline-3-ene synthesis
- Product Name:Methyl N-Boc-L-proline-3-ene
- CAS Number:74844-93-2
- Molecular formula:C11H17NO4
- Molecular Weight:227.26
51154-06-4
138 suppliers
$12.00/100mg
18107-18-1
210 suppliers
$33.00/5g
74844-93-2
107 suppliers
$34.00/100mg
Yield:74844-93-2 100%
Reaction Conditions:
Stage #1: (S)-2,5-dihydropyrrole-1,2-dicarboxylic acid 1-tert-butyl ester;diazomethyl-trimethyl-silane in methanol;hexane;toluene at 0; for 0.75 h;
Stage #2: with acetic acid in methanol;hexane;toluene;Product distribution / selectivity;
Steps:
2.a
(Trimethylsilyl)diazomethane (2.0 M solution in hexane, 200 mL, 400 mmol) was added dropwise over 15 minutes to a stirred mixture of toluene (600 mL), methanol (100 mL) and (S)-Boc-3,4-dehydroproline (1) (ex. Bachem, 50 g, 234.4 mmol) whilst EPO
References:
WO2007/17698,2007,A1 Location in patent:Page/Page column 30-31
74844-91-0
414 suppliers
$5.00/5g
74844-93-2
107 suppliers
$34.00/100mg
84520-67-2
65 suppliers
$14.00/250mg
74844-93-2
107 suppliers
$34.00/100mg
51154-06-4
138 suppliers
$12.00/100mg
80-48-8
453 suppliers
$5.00/25g
74844-93-2
107 suppliers
$34.00/100mg
629616-63-3
1 suppliers
inquiry
74844-93-2
107 suppliers
$34.00/100mg