Minoxidil synthesis
- Product Name:Minoxidil
- CAS Number:38304-91-5
- Molecular formula:C9H15N5O
- Molecular Weight:209.25
110-89-4
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38304-91-5
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Yield:38304-91-5 86.2%
Reaction Conditions:
at 103; for 4 h;Large scale;Concentration;
Steps:
1.B; 1.C; 2.B; 2.C B. Synthesis of Crude Minoxidil
13.08mol of 2,4-diamino-6-chloropyrimidine-1-oxide and 18.06kg of piperidine were added to the double-layer glass reaction kettle, the temperature was raised to 103°C with stirring, and the reaction was refluxed for 4 hours. The reaction end was monitored by TLC chromatographic plate.After the reaction was completed, the temperature was lowered to 5°C with stirring, overnight crystallization, suction filtration, the filter cake was washed with piperidine once, and dried to obtain 2.74 kg of off-white solid minoxidil crude product, the product purity was 97.39%, and the yield was 100%. .C. Synthesis of Minoxidil2.6kg of the minoxidil crude product, 6.1kg of isopropanol and 7.8kg of purified water were added to the double-layer glass reaction kettle, and the temperature was raised to 76°C with stirring, and the reflux reaction was performed for 1 hour to make the system clear; the temperature was lowered to 5°C with stirring, Crystallization overnight, suction filtration, the filter cake was washed once with isopropanol, and dried to obtain 2.24 kg of off-white solid minoxidil, the product purity was 100%, and the yield was 86.2%.
References:
CN113979952,2022,A Location in patent:Paragraph 0040; 0043-0046; 0049; 0052-0055
35139-67-4
178 suppliers
$60.00/250mg
38304-91-5
743 suppliers
$7.00/1g
65277-42-1
959 suppliers
$7.00/1g
38304-91-5
743 suppliers
$7.00/1g