一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List mPEG8-Alkyne
880081-81-2

mPEG8-Alkyne synthesis

1synthesis methods
-

Yield:880081-81-2 96%

Reaction Conditions:

Stage #1: 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanolwith sodium hydride in tetrahydrofuran at 0 - 5; for 0.0833333 h;
Stage #2: propargyl bromide in tetrahydrofuran at 0 - 5; for 1 h;

Steps:

261a Intermediate 261a

Into a 500-mL round-bottom flask, was placed a solution of 2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol (15 g, 39.06 mmol, 1.00 equiv) in tetrahydrofuran (150 mL).
This was followed by the addition of sodium hydride (1.9 g, 79.17 mmol, 1.01 equiv), in portions at 0-5° C. in 5 min.
To this was added a solution of 3-bromoprop-1-yne (9.3 g, 78.81 mmol, 2.02 equiv) in toluene (20 mL) dropwise with stirring at 0-5° C. in 5 min.
The resulting solution was stirred for 1 h at 0-5° C. in a water/ice bath.
The reaction progress was monitored by LCMS/TLC (ethyl acetate/petroleum ether=1:1).
The solids were filtered out.
The resulting mixture was concentrated under vacuum.
This resulted in 15.9 g (96%) of 3-(2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)prop-1-yne as brown oil

References:

US9301951,2016,B2 Location in patent:Page/Page column 494

mPEG8-Alkyne Related Search:

青河县| 青川县| 江华| 巴中市| 孙吴县| 郧西县| 白朗县| 沂源县| 平邑县| 桐柏县| 德惠市| 荣成市| 瑞金市| 额尔古纳市| 定安县| 申扎县| 海南省| 阿勒泰市| 富锦市| 拉萨市| 丰城市| 离岛区| 南郑县| 清水河县| 光泽县| 高平市| 横峰县| 云霄县| 南木林县| 汶川县| 贵州省| 安徽省| 汉川市| 荔浦县| 阳泉市| 阜阳市| 丹阳市| 台州市| 克山县| 绥中县| 海晏县|