N-(1-Cyclohexen-1-yl)morpholine synthesis
- Product Name:N-(1-Cyclohexen-1-yl)morpholine
- CAS Number:670-80-4
- Molecular formula:C10H17NO
- Molecular Weight:167.25
110-91-8
108-94-1
670-80-4
The general procedure for the synthesis of 1-morpholino-1-cyclohexene from morpholine and cyclohexanone is as follows: to a solution of morpholine (10.5 mL, 0.12 mol, 1.2 eq.) in anhydrous toluene (70 mL) was added cyclohexanone (10.4 mL, 0.10 mol, 1.0 eq.), followed by the addition of p-toluenesulfonic acid (0.20 g, 1.16 mmol. 0.016 eq.) as a catalyst. The reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the reaction solution was cooled and subsequently concentrated under reduced pressure to afford the target product 1-morpholino-1-cyclohexene in 85% yield.
Yield:670-80-4 98%
Reaction Conditions:
with sulfuric acid in toluene;Dean-Stark;Reflux;
References:
Sinha, Jasmine;Soars, Shafer;Bowman, Christopher N. [Macromolecules,2021,vol. 54,# 4,p. 1693 - 1701]
110-91-8
706 suppliers
$9.00/1g
108-94-1
594 suppliers
$12.00/50g
670-80-4
155 suppliers
$19.00/10g
92-53-5
191 suppliers
$14.00/1g
110-91-8
706 suppliers
$9.00/1g
108-94-1
594 suppliers
$12.00/50g
6425-41-8
41 suppliers
inquiry
670-80-4
155 suppliers
$19.00/10g
92-53-5
191 suppliers
$14.00/1g
