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ChemicalBook CAS DataBase List N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE
142128-47-0

N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE synthesis

2synthesis methods
-

Yield:142128-47-0 57%

Reaction Conditions:

Stage #1: 1-hexadecylcarboxylic acidwith benzotriazol-1-ol;O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;triethylamine in dichloromethane; for 0.5 h;
Stage #2: (R)-2-aminopropan-1-ol in dichloromethane;

References:

Ghidini, Andrea;Scalvini, Laura;Palese, Francesca;Lodola, Alessio;Mor, Marco;Piomelli, Daniele [Journal of Enzyme Inhibition and Medicinal Chemistry,2021,vol. 36,# 1,p. 1411 - 1423]

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