n-Butyl cyanoacetate synthesis
- Product Name:n-Butyl cyanoacetate
- CAS Number:5459-58-5
- Molecular formula:C7H11NO2
- Molecular Weight:141.17
372-09-8
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71-36-3
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5459-58-5
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Yield:5459-58-5 95%
Reaction Conditions:
with sulfuric acid;acetonitrile at 80 - 85; for 16 - 18 h;
Steps:
Procedure for cyano acid (Table 2, entry 16b-21b):
General procedure: To a well-stirred mixture of cyano acid (80 mmol) in alcohol (90 mmol), and acetonitrile (162 mmol) , added sulfuric acid (98%, 94 mmol, 5 mL) at room temperature and temperature maintained between 80-85°C for 16-18h. The reaction mixture was cooled and added to 20% sodium carbonate solution (100 mL). The reaction mass was extracted in CH2Cl2 (50 mL × 2). The combined organic layer was washed with water (100 mL), dried over sodium sufate, and concentrated under reduced pressure to obtain product (85-95%). Most example gave NMR pure product. Where minor impurities are formed, the product was purified over silica gel using ethyl acetate: petroleum ether (1:9).
References:
Dawar, Pankaj;Raju, M. Bagavan;Ramakrishna, Ramesha Andagar [Synthetic Communications,2014,vol. 44,# 6,p. 836 - 846] Location in patent:supporting information
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5459-58-5
203 suppliers
$12.00/25g
372-09-8
367 suppliers
$20.00/25g
5459-58-5
203 suppliers
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109-77-3
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71-36-3
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5459-58-5
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$12.00/25g
1190-39-2
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109-65-9
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372-09-8
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$20.00/25g
5459-58-5
203 suppliers
$12.00/25g