N-CBZ-LEU-LEU METHYL ESTER synthesis
- Product Name:N-CBZ-LEU-LEU METHYL ESTER
- CAS Number:3504-37-8
- Molecular formula:C21H32N2O5
- Molecular Weight:392.49
Yield:3504-37-8 90%
Reaction Conditions:
Stage #1: Z-Leu-OHwith 4-methyl-morpholine;isobutyl chloroformate in tetrahydrofuran at -20; for 0.5 h;Inert atmosphere;
Stage #2: (S)-Leu-OMewith 4-methyl-morpholine in tetrahydrofuran at -20 - 20; for 19 h;Inert atmosphere;
References:
Border, Sarah E.;Caffrey, Conor R.;Corrigan, Thomas S.;Do?an Ekici, ?zlem;Fajtova, Pavla;Hadad, Christopher M.;Kasper, Kayla Q.;Lotti Diaz, Leilani M.;McElroy, Craig A.;Ratigan, Steven C.;Salvesen, Guy S.;Sojka, Daniel [Journal of Enzyme Inhibition and Medicinal Chemistry,2020,vol. 35,# 1,p. 1387 - 1402]
2018-66-8
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