一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List N-desmethyl?Apalutamide
1332391-11-3

N-desmethyl?Apalutamide synthesis

11synthesis methods
Apalutamide Acid Impurity

1332391-04-4
29 suppliers
inquiry

N-desmethyl?Apalutamide

1332391-11-3
51 suppliers
inquiry

-

Yield:-

Reaction Conditions:

Stage #1: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoic acidwith oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 4 h;
Stage #2: with ammonia in 1,4-dioxane at 20;

Steps:

34

To a suspension of 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7- diazaspiro[3.4]octan-5-yl)-2-fluorobenzoic acid (Compound 224, 500 mg, 1.08 mmol) in DCM was added DMF (cat., 0.1 mL), followed by oxalyl chloride (0.14 mL, 1.61 mmol). The mixture was stirred at room temperature for 4h then concentrated in vacuo to produce a yellow residue that was further dried on a high vacuum pump. Ammonia (0.5M in dioxane, 40 mL, 20 mmol) was directly added to the residue and the mixture was stirred at room temperature overnight. MeOH was added and the mixture was absorbed onto silica gel and purified by flash chromatography (50 to 100% EtOAc/Hexanes) to afford impure desired product that was repurified by reverse phase HPLC (acetonitrile/water:TFA). The fractions containing the desired compound were combined, acetonitrile was removed in vacuo, and the remaining aqueous layer was treated with a saturated solution of sodium bicarbonate. The aqueous layer was extracted with DCM (3x), the organics were combined, dried over sodium sulfate, and evaporated to dryness to afford 100 mg of 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8- oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide as a white solid. lK NMR (300 MHz, DMSO-de) δ 9.21 (s, 1H), 8.75 (s, 1H), 7.95 (s, 1H), 7.87 (t, 1H), 7.80 (s, 1H), 7.46 (dd, 1H), 7.37 (dd, 1H), 2.69-2.62 (m, 2H), 2.55-2.47 (m, 2H), 2.00 (m, 1H), 1.58 (m, 1H).

References:

WO2011/103202,2011,A2 Location in patent:Page/Page column 200; 201

573762-62-6 Synthesis
5-Amino-3-(trifluoromethyl)picolinonitrile

573762-62-6
256 suppliers
inquiry

N-desmethyl?Apalutamide

1332391-11-3
51 suppliers
inquiry

887707-23-5 Synthesis
5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE

887707-23-5
118 suppliers
$28.00/1g

N-desmethyl?Apalutamide

1332391-11-3
51 suppliers
inquiry

887707-25-7 Synthesis
2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

887707-25-7
131 suppliers
$20.00/1g

N-desmethyl?Apalutamide

1332391-11-3
51 suppliers
inquiry

N-desmethyl?Apalutamide Related Search:

新营市| 广饶县| 永安市| 荥阳市| 扶沟县| 连平县| 治县。| 巴马| 金华市| 兴业县| 兴业县| 新安县| 建水县| 宁陕县| 琼结县| 达州市| 通州市| 平定县| 财经| 阿拉尔市| 湛江市| 祁门县| 宣威市| 吕梁市| 临海市| 隆安县| 波密县| 社旗县| 南宁市| 望城县| 澄迈县| 陆良县| 沈丘县| 胶南市| 崇明县| 金寨县| 饶阳县| 格尔木市| 泸西县| 沾化县| 六枝特区|